The plant belongs to the family Cannabaceae Urticales. Two main species may be recognized: Cannabis sativa and Cannabis indica.
Plants of this species contain many psychoactive components, the cannabinoids, including the primary psychoactive compound Δtetrahydrocannabinol THCthe active substance present in Marijuana. The history of its cultivation and use dates back thousands of dating user marijuana. A possible first documented use for medical purposes of this drug is found in Chinese records dated from 28th century BC.
Moreover, the presence of THC has been detected in several internal organs from an Egyptian mummy with a 14 C-dating of approximately BC. Evidence of therapeutic potential for marijuana and its components has been suggested for a large number of medical conditions.
Despite this, a variety of cardiovascular complications have been documented. Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-coupled cannabinoid receptors CB1 and CB2 has been, in fact, linked to different cardiovascular pathologies.
Here, we describe a timely update of possible cardiovascular effects of its use for medical purposes.